Meredith: "Derek, she's your sister, you can buy her a cup of coffee."
Derek: "I have a lot of sisters and if I bought them all coffee we wouldn't have anything."

Derek: "What's going on? You think I'm gonna let you do to him what you did to my Mustang? I don't think so." (Amelia leaves)
Meredith: "She's your sister. You're being like this because she crashed your car a couple of years ago? I totaled my moms car, people make mistakes."
Derek: "Mer, when you totaled your moms car, were you high on pain pills?"
Meredith: "No."
Derek: "Did you steal your mother's prescription pad so you could feed your addiction?"
Meredith: "She stole your prescription pad?"
Derek: "Yeah, and then when she went home, she OD-ed. She was dead for three minutes, I saved her. That's what she put my mother through after loosing my father and raising five kids on her own. So no, I don't trust her in my OR. Okay?"

Derek: "We were in the back of the store. Dad has just given you two pennies. And you always hid them behind the counter in this big crack in the floorboards. You said you're saving them so you could buy a town. And then the two guys came in, we could hear them talking but we weren't paying attention until dad yelled. And you looked up. They had already pulled the gun, and they had already taken the money... And now they wanted the watch that mom gave him. He wouldn't give it up. It was a gunshot, you lunched forward..."
Amelia: "I remember, I was trying to get to him but... I couldn't move."
Derek: "Because I was holding you so tight that you couldn't budge. Put one hand over your mouth so you wouldn't scream and wrapped the other one around you and just held on for your life. Prayed to God that you would be quiet and wouldn't say anything. You were so little. I think that's what I've always wanted all this year, you just to stay... little and quiet and safe. But you're not any of those things. You're loud and fearless and that scared the crap out of me. How am I supposed to call you and tell you that I've been shot? I can't tell you about my pain. I don't want you to know that the pain exists." (he hugs her)

Most surgeons grew up being freaks. While other kids played outside, we hold up in our rooms, memorizing the periodic table, hovering for hour over our genuine microscopes, dissecting our first frogs. Imagine how surprised and relieved we were when we grew up and found out that others out there are just as freaky as we were. Same microscopes, same dead frogs, same inexplicable urge to take human beings apart.

Nobody chooses to be a freak. Most people don't even realize they're freak until it's too late to change it. But no matter how much of a freak you end up being, chances are there's still someone out there for you. Unless of course they've already moved on. Because when it comes to love, even freaks can't wait forever.