Meredith: "What are you starting with?"
Derek: *medical talk*
Meredith: "Are you doing it open, or endoscopically?"
Derek: "I'm not gonna do this."
Meredith: "What?"
Derek: "You're the one who left Neuro."
Meredith: "I know."
Derek: "I'm not gonna do this whole thing where you're sad about every case that I have."
Meredith: "I'm not sad. I'm trying to start a conversation."
Derek: "Okay, well… make conversation about something else. I gotta go."

Derek: "A few weeks ago, I knew exactly how the next ten years would play out. Work, family… and then, I lost the trial, baby, blacklisted by FDA and Meredith… some days I miss her so much I don't know if I'm gonna make it."

There are distinct differences between male and female brains. Female brains have a larger Hippocampus. Which usually makes them better at attention and memory. Male brains have a bigger parietal cortex. Which helps when fending off an attack. Male brains confront challenges differently than female brains. Woman are hardwired to communicate with language, detail, empathy. Men, not so much. It doesn't mean that we're any less capable of emotion. We can talk about our feelings, it's just that… most of the time, we'd really rather not. 

Be a man. People say it all the time. But what does that even mean? Is it about strength? Is it about sacrifice? Is it about winning? Maybe it's simpler than that. You have to know when not to man up. Sometimes it takes a real men to set his ego aside, admit defeat and start all over again.